1995: The Dynamics of Protein Kinesis, Vol. LX
Organizer: Bruce Stillman
Symposium Participants v Foreword xix Protein Translocation in the Endoplasmic Reticulum and Golgi Unidirectional and Bidirectional Protein Traffic across Membranes G. Blobel 1 Coat Proteins and Selective Protein Packaging into Transport Vesicles R. Schekman, C. Barlowe, S. Bednarek, J. Campbell, T. Doering, R. Duden, M. Kuehn, M. Rexach, T. Yeung, and L. Orci 11 Targeting Pathways to the Endoplasmic Reticulum Membrane J.D. Brown, D.T.W. Ng, S.C. Ogg, and P. Walter 23 Posttranslational Protein Transport into the Endoplasmic Reticulum S. Panzner, L.Dreier, E. Hartmann, S. Kostka, and T.A. Rapoport 31 Protein Insertion into the Membrane of the Endoplasmic Reticulum: The Architecture of the Translocation Site B. Martoglio and B. Dobberstein 41 Nascent-polypeptide-associated Complex: A Bridge between Ribosome and Cytosol B. Lauring, S. Wang, H. Sakai, T.A. Davis, B. Wiedmann, G. Kreibich, and M. Wied-Mann 47 Protein-conducting Channels for the Translocation of Proteins into and across Membranes S.M. Simon 57 The Environment of Nascent Secretory and Membrane Proteins at the Endoplasmic Reticulum Membrane during Translocation and Integration A.E. Johnson, S. Liao, J. Lin, B. Hamman, H. Do, A. Cowie, and D.W. Andrews 71 The Saccharomyces cerevisiae Oligosaccharyltransferase: A Large Hetero-oligomeric Complex in the Endoplasmic Reticulum D. Karaoglu, S. Silberstein, D.J. Kelleher, and R. Gilmore 83 The Erythropoietin Receptor: Biogenesis, Dimerization, and Intracellular Signal Transduction H.F. Lodish, D.J. Hilton, U. Klingmüller, S.S. Watowich, and H. Wu 93 SNAREs Involved in Traffic through the Golgi Complex H.R.B Pelham, D.K. Banfield, and M.J. Lewis 105 Targeting to the Endoplasmic Reticulum by Dilysine Motifs: Role of Coat Proteins P. Cosson and F. Letourneur 113 Factors Mediating the Late Stages of ER-to-Golgi Transport in Yeast Y. Jiang, M. Sacher, B. Singer-Krüger, J.P. Lian, S. Stone, and S. Ferro-Novick 119 Regulated Export of Cargo from the Endoplasmic Reticulum of Mammalian Cells S. Bannykh, M. Aridor, H. Plutner, T. Rowe, and W.E. Balch 127 Molecules and Vesicle Coats Involved in the Budding of Exocytotic Vesicles from the trans-Golgi Network J. Wang, M.S. Ladinsky, and K.E. Howell 139 Mapping a Retention Signal for Golgi Localization of a Viral Spike Protein ComplexR.F. Pettersson, A. Andersson, and L. Melin 147 Novel Protein Kinase/Phosphatidylinositol 3-Kinase Complex Essential for Receptormediated Protein Sorting to the Vacuole in Yeast J.H. Stack, P.K. Herman, D.B. DeWald, E.G. Marcusson, J. Lin Cereghino, B.F. Horazdovsky, and S.D. Emr 157 Protein Trafficking at the Cell Surface Control of Exocytosis in Yeast P. Novick, M.D. Garrett, P. Brennwald, A. Lauring, F.P. Finger, R. Collins, and D.R. TerBush 171 Regulation of Post-Golgi Vesicle Production in an In Vitro System J.-P. Simon, I.E. Ivanov, M. Ren, J. Zeng, B. Shopsin, D. Hersh, P. Tempst, H. Erdjument-Bromage, M. Lui, C. De Lemos-Chiarandini, M. Rosenfeld, D. Gravotta, T. Morimoto, M. Adesnik, and D.D. Sabatini 179 Late ATP-dependent and Ca++ -activated Steps of Dense Core Granule ExocytosisT.F.J. Martin, J.C. Hay, A. Banerjee, V.A. Barry, K. Ann, H.-C. Yom, B.W. Porter, and J.A. Kowalchyk 197 Membrane Transport from Early to Late Endosomes F. Aniento and J. Gruenberg 205 The GDP/GTP Cycle of Rab5 in the Regulation of Endocytotic Membrane Traffic G.Vitale, K. Alexandrov, O. Ullrich, H. Horiuchi, A. Giner, C. Dobson, O. Baykova, H. Gournier, H. Stenmark, and M. Zerial 211 Selective Membrane Recruitment of Rab GTPases S.R. Pfeffer, T. Soldati, H. Geissler, C. Rancaño, and B. Dirac-Svejstrup 221 The ARF GTPases: Defining Roles in Membrane Traffic and Organelle Structure J.G. Donaldson, H. Radhakrishna, and P.J. Peters 229 Role of Dynamin in Clathrin-coated Vesicle Formation T. Baba, H. Damke, J.E. Hinshaw, K. Ikeda, S.L. Schmid, and D.E. Warnock 235 Inhibitors That Block Both the Internalization of Caveolae and the Return of Plasmalemmal Vesicles E.J. Smart, K. Estes, and R.G.W. Anderson 243 Assembly and Intracellular Transport of MHC Class I and Class II Molecules M.R. Jackson, K. Früh, L. Karlsson, L. Teyton, Y. Yang, and P.A. Peterson 249 Trafficking and Assembly of MHC Molecules: How Viruses Elude the Immune SystemH.L. Ploegh 263 Assembly, Peptide Loading, and Transport of MHC Class I Molecules in a Calnexin-negative Cell Line B.K. Sadasivan, A. Cariappa, G.L. Waneck, and P. Cresswell 267 Essential Features of the Pathway for Protein Translocation across the Escherichia coli Cytoplasmic Membrane C. Murphy, W. Prinz, M. Pohlschrîder, A. Derman, and J. Beckwith 277 On the Road to Translocase W. Wickner, M.R. Leonard, and A. Economou 285 Sequence Comparison of Yeast ATP-binding Cassette Proteins S. Michaelis and C. Berkower 291 Synaptic Trafficking A Systematic Approach to Studying Synaptic Function in Vertebrates R. Janz and T.C. Südhof 309 Biogenesis of Neurosecretory Vesicles W.B. Huttner, M. Ohashi, R.H. Kehlenbach, F.A. Barr, R. Bauerfeind, O. Bräunling, D. Corbeil, M. Hannah, H.A. Pasolli, A. Schmidt, A.A. Schmidt, C. Thiele, Y. Wang, A. Krîmer, and H.-H. Gerdes 315 Botulinum and Tetanus Neurotoxins: Emerging Tools for the Study of Membrane Fusion R. Jahn, P.I. Hanson, H. Otto, and G. Ahnert-Hilger 329 Proteins Involved in Synaptic Vesicle Docking and Fusion M.E. Burns, S.A. Beushausen, G.J. Chin, D. Tang, W.M. DeBello, T. Dresbach, V. O'Connor, F.E. Schweizer, S.S.-H. Wang, S.W. Whiteheart, L.A. Hawkey, H. Betz, and G.J. Augustine 337 Calcium-dependent Vesicular Exocytosis: From Constitutive to Regulated SecretionM. Poo, Y. Dan, H. Song, T. Morimoto, and S. Popov 349 Insights into the Molecular Mechanisms of Synaptic Vesicle Docking and Fusion A.E.Ting and R.H. Scheller 361 Drosophila Genetics and the Functions of Synaptic Proteins K. Parfitt, N. Reist, J. Li, R. Burgess, D. Deitcher, A. DiAntonio, and T.L. Schwarz 371 Recycling of Synaptic Vesicle Membrane Components Y. Kaneda, E. Grote, F. Bonzelius, C. Desnos, G. Herman, L. Clift-O'Grady, and R.B. Kelly 379 The Last Seconds in the Life of a Secretory Vesicle T.D. Parsons, J.R. Coorssen, H. Horstmann, A.K. Lee, F.W. Tse, and W. Almers 389 Molecular Mechanisms in Synaptic Vesicle Endocytosis R. Bauerfeind, C. David, T. Galli, P.S. McPherson, K. Takei, and P. De Camilli 397 Protein Folding Calnexin, Calreticulin, and Bip/Kar2p in Protein Folding D.N. Hebert, J.F. Simons, J.R. Peterson, and A. Helenius 405 Binding Sites for Hsp70 Molecular Chaperones in Natural Proteins M.-J. Gething, S. Blond-Elguindi, J. Buchner, A. Fourie, G. Knarr, S. Modrow, L. Nanu, M. Segal, and J. Sambrook 417 Mechanisms and Pathways of Chaperone-mediated Protein Folding F.U. Hartl 429 Kinesis of Polypeptide during GroEL-mediated Folding A.L. Horwich, J.S. Weissman, and W.A. Fenton 435 Complex Multigene Family of Functionally Distinct Hsp70s of Yeast E. Craig, T. Ziegelhoffer, J. Nelson, S. Laloraya, and J. Halladay 441 The Role of Hsp104 in Stress Tolerance and [PSI+] Propagation in Saccharomyces cerevisiae S. Lindquist, M.M. Patino, Y.O. Chernoff, A.S. Kowal, M.A. Singer, S.W.Liebman, K.-H. Lee, and T. Blake 451
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Protein Degradation The N-end Rule A. Varshavsky 461 Functions of the Proteasome in Antigen Presentation A.L. Goldberg, M. Gaczynska, E. Grant, M. Michalek, and K.L. Rock 479 The Ubiquitin-mediated Proteolytic System: Involvement of Molecular Chaperones, Degradation of Oncoproteins, and Activation of Transcriptional Regulators A. Ciechanover, A. Laszlo, B. Bercovich, I. Stancovski, I. Alkalay, Y. Ben-Neriah, and A. Orian 491 The DOA Pathway: Studies on the Functions and Mechanisms of Ubiquitin-dependent Protein Degradation in the Yeast Saccharomyces cerevisiae M. Hochstrasser, F.R. Papa, P. Chen, S. Swaminathan, P. Johnson, L. Stillman, A.Y. Amerik, and S.-J. Li 503 Structure and Function of the 20S Proteasome and of Its Regulatory Complexes A. Lupas, P. Zwickl, T. Wenzel, E. Seemüller, and W. Baumeister 515 Catalytic Mechanism of the 20S Proteasome of Thermoplasma acidophilum Revealed by X-ray Crystallography D. Stock, L. Ditzel, W. Baumeister, R. Huber, and J. Löwe 525 Selective, Energy-dependent Proteolysis in Escherichia coli S. Gottesman, S. Wickner, Y. Jubete, S.K. Singh, M. Kessel, and M. Maurizi 533 Membrane Dynamics Mitotic Disassembly and Reassembly of the Golgi Apparatus T.P. Levine, T. Misteli, C. Rabouille, and G. Warren 549 Reconstitution of Golgi Stacks from Vesiculated Golgi Membranes in Permeabilized Cells U. Acharya and V. Malhotra 559 Regulation of Endocytosis, Exocytosis, and Shape by Membrane Tension J. Dai and M.P. Sheetz 567 Membrane Fusion by Influenza Hemagglutinin J.J. Skehel, T. Bizebard, P.A. Bullough, F.M. Hughson, M. Knossow, D.A. Steinhauer, S.A. Wharton, and D.C. Wiley 573 Membrane Fusion: The Influenza Paradigm J.M. White 581 Intermediates in Membrane Fusion J. Zimmerberg, S.S. Vogel, T. Whalley, I. Plonsky, A. Sokoloff, A. Chanturia, and L.V. Chernomordik 589 Role of Water in Short-range Repulsive and Attractive Interactions between Macromolecules and Bilayers S.A. Simon and T.J. McIntosh 601 Protein Import into Organelles Import and Folding of Proteins by Mitochondria T. Lithgow, M. Horst, S. Rospert, A. Matouschek, V. Haucke, and G. Schatz 609 Dissection of Protein Translocation across the Mitochondrial Outer and Inner Membranes M. Brunner, H.-C. Schneider, R. Lill, and W. Neupert 619 Molecular Dissection of the Mechanism of Protein Import into Chloroplasts F. Tian, Y. Ma, A. Kouranov, S.E. LaSala, and D.J. Schnell 629 Characterization of the Yeast and Human Receptors for the Carboxy-terminal Tripeptide Peroxisomal Targeting Signal E.A.C. Wiemer, S.R. Terlecky, W.M. Nuttley, and S. Subramani 637 Transport of Proteins and Metabolites across the Impermeable Membrane of Peroxisomes H.F. Tabak, Y. Elgersma, E. Hettema, M.M. Franse, T. Voorn-Brouwer, and B. Distel 649 Protein Import into Peroxisomes: An Exception to the Rule? B. Huhse and W.-H. Kunau 657 Nuclear Trafficking Signal Sequences That Target Nuclear Import and Nuclear Export of Pre-mRNA-binding Proteins W.M. Michael, H. Siomi, M. Choi, S. Piñol-Roma, S. Nakielny, Q. Liu, and G. Dreyfuss 663 Nuclear Localization of a Cap-binding Protein Complex E. Izaurralde, C. McGuigan, and I.W. Mattaj 669 Nucleocytoplasmic Trafficking: What Role for Repeated Motifs in Nucleoporins? E. Fabre, N.L. Schlaich, and E.C. Hurt 677 Cytoplasmic Factors in NLS-mediated Targeting to the Nuclear Pore Complex S.A. Adam, E.J.H. Adam, N.C. Chi, and G.D. Visser 687 Roles of Importin in Nuclear Protein Import D. Görlich and R.A. Laskey 695 Soluble Factors Required for Nuclear Protein Import M.S. Moore and G. Blobel 701 Biochemical and Structural Analysis of Nuclear Protein Import F. Melchior, T. Guan, B. Paschal, and L. Gerace 707 Cell Polarity Programming of Cell Polarity in Budding Yeast by Endogenous and Exogenous SignalsI. Herskowitz, H.-O. Park, S. Sanders, N. Valtz, and M. Peter 717 Establishment of Cell Polarity in Yeast J.R. Pringle, E. Bi, H.A. Harkins, J.E. Zahner, C. De Virgilio, J. Chant, K. Corrado, and H. Fares 729 Molecular Sorting of Membrane Proteins in Polarized and Nonpolarized Cells I. Mellman 745 Dissecting the Molecular Mechanisms of Polarized Membrane Traffic: Reconstitution of Three Transport Steps in Epithelial Cells Using Streptolysin-O PermeabilizationF. Lafont, K. Simons, and E. Ikonen 753 Generation of Epithelial Cell Polarity: Roles for Protein Trafficking, Membrane-Cytoskeleton, and E-Cadherin-mediated Cell Adhesion R.W. Mays, W.J. Nelson, and J.A. Marrs 763 Regulation of Protein Traffic in Polarized Epithelial Cells: The Polymeric Immunoglobulin Receptor Model K.E. Mostov, Y. Altschuler, S.J. Chapin, C. Enrich, S.-H. Low, F. Luton, J. Richman-Eisenstat, K.L. Singer, K. Tang, and T. Weimbs 775 Molecular Motors Myosin Structure and Function J.A. Spudich, J. Finer, B. Simmons, K. Ruppel, B. Patterson, and T. Uyeda 783 Statistical Kinetics of Processive Enzymes M.J. Schnitzer and S.M. Block 793 Targeting of Cytoplasmic Dynein to Membranous Organelles and Kinetochores via Dynactin R.B. Vallee, K.T. Vaughan, and C.J. Echeverri 803 Analysis of Nuclear Migration in Aspergillus nidulans X. Xiang, A.H. Osmani, S.A. Osmani, C.H. Roghi, D.A. Willins, S. Beckwith, G. Goldman, Y. Chiu, M. Xin, B. Liu, and N.R. Morris 813 |
